Basepair
Web App
An EHR-embedded pharmacogenomics safety service that catches dangerous drug-gene mismatches at prescribing time. It gates each alert on a pharmacist's one-click sign-off with the exact CPIC guideline citation. Built for the Built with Claude: Life Sciences hackathon.
Next.js
TypeScript
Claude Opus 4.8
Vercel AI SDK
Medplum
FHIR
Trigger.dev
Drizzle
Supabase
Pharmacogenomics
Open Source
Key Features
- Deterministic clinical core that covers 2,115 CPIC rules across 19 genes
- LLM verifier grades every alert against the literal guideline text to suppress false positives
- Durable, approval-gated evaluation loop over Trigger.dev with wait-token pharmacist sign-off
- EHR integration via Medplum (FHIR datastore, SMART on FHIR auth, CDS Hooks trigger)
- Prescriber-facing CDS card, pharmacist console, and full audit view
- Agent parses messy free-text genotype notes. Clinical decisions stay deterministic
- Writes DetectedIssue, Task, Communication, AuditEvent, and Provenance FHIR resources